随着药物数目的迅速增加,强有力药物的研制,多剂疗法的泛滥,体内药物动态学研究的进步以及药物信息系统的发展等,人们越来越清楚地认识到药物损害的主要原因来自药物的相互作用。自1975年Cluff 等提出药物相互作用信息数高达6000以来,目前恐怕远远超出此数值。但并不能说所有报告的相互作用信息都反映临床上的现实问题。因此必须从临床医学的角度重新考虑药物相互作用信息的重要性。一、药物相互作用的分类与机制 With the rapid increase in the number of drugs, the development of powerful drugs, the proliferation of multi-dose therapies, advances in in vivo pharmacokinetics and the development of drug information systems, it is increasingly clear that the major causes of drug damage come from drugs Interaction. Since 1975, Cluff et al. Proposed that the number of drug interactions information up to 6000, I am afraid that far far beyond this value. However, it can not be said that all reported information on interactions reflects clinical realities. Therefore, the importance of information on drug interactions must be reconsidered from a clinical perspective. First, the classification and mechanism of drug interactions