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在历史悠久的中国酒文化的熏陶下,我国作为酒精的消费大国,消费人群多年居高不下,研究表明适量摄入酒精对健康没有损害,但长期大量的饮酒会造成神经系统、消化系统的严重损害。有研究显示超过4年,肝硬化叠加酒精性肝炎患者死亡率大于60%,且在患病的第一个月发生大部分死亡。因此,我们可以预见这种疾病是比许多常见类型的癌症(例如:乳腺癌,前列腺癌和结肠癌)更不祥。此外,ALD患者承担着医疗费用的经济负担。不幸的是,食品和药物管理局批准仍没有对ALD的任何阶段的或广泛有效的药物疗法。因此,我们迫切需要更详细的了解肝损伤的机制。酒精性肝病的发病机制十分复杂,多种器官系统、物质代谢、反应过程、信号转导通路、细胞因子参与其中。本研究对ALD分子发病机制进行综述。
Under the long history of Chinese wine culture, China, as a large consuming country of alcohol, has a high consumption group for many years. Studies have shown that moderate intake of alcohol does not harm health, but long-term heavy drinking can cause severe nervous system and digestive system damage. Studies have shown that for more than 4 years, mortality from liver cirrhosis with alcoholic hepatitis is greater than 60% and most of the death occurs in the first month of illness. Therefore, we can predict that this disease is more ominous than many common types of cancers (eg, breast, prostate and colon). In addition, ALD patients bear the financial burden of medical expenses. Unfortunately, the Food and Drug Administration has not approved any phase of the widespread or effective pharmacotherapy of ALD. Therefore, we urgently need a more detailed understanding of the mechanism of liver injury. The pathogenesis of alcoholic liver disease is very complex, a variety of organ systems, substance metabolism, reaction processes, signal transduction pathways, cytokines involved. This study summarizes the pathogenesis of ALD.