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目的研究不同剂量戊酸雌二醇对宫腔镜术后宫腔粘连状况的影响。方法选取2013年3月~2014年5月该院收治的宫腔镜手术患者70例,根据随机数字表法将患者分为A组和B组,每组35例。其中A组给予戊酸雌二醇3 mg/次,1次/d,B组给予戊酸雌二醇3 mg/次,3次/d,两组均用药3个月。治疗后行超声检测两组子宫内膜厚度,并比较两组患者临床疗效、宫腔粘连发生率、月经恢复率及不良反应发生率。结果 B组总有效率(97.1%)显著高于A组(68.6%),两组比较差异有统计学意义(P<0.05);B组宫腔粘连发生率显著低于A组,月经恢复率显著高于A组,两组比较差异均有统计学意义(P<0.05);B组子宫内膜厚度显著大于A组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论每天应用9 mg戊酸雌二醇应用于宫腔镜术后具有较好的疗效,能有效促进患者月经恢复,促进子宫内膜增生,有效防止宫腔再粘连。
Objective To study the effect of different doses of estradiol valerate on intrauterine adhesions after hysteroscopy. Methods Seventy patients underwent hysteroscopic surgery in our hospital from March 2013 to May 2014. The patients were divided into group A and group B according to the random number table method, with 35 cases in each group. The patients in group A received estradiol valerate 3 mg once daily, while the patients in group B received estradiol valerate 3 mg thrice daily for 3 months. After treatment, the thickness of endometrium in both groups was detected by ultrasound, and the clinical curative effect, intrauterine adhesions incidence, menstruation recovery rate and incidence of adverse reactions were compared between the two groups. Results The total effective rate (97.1%) in group B was significantly higher than that in group A (68.6%), the difference between the two groups was statistically significant (P <0.05). The incidence of intrauterine adhesions in group B was significantly lower than that in group A (P <0.05). The thickness of endometrium in group B was significantly higher than that in group A (P <0.05). The incidence of adverse reactions in both groups was significantly higher than that in group A , The difference was not statistically significant (P> 0.05). Conclusion The application of 9 mg estradiol valerate daily has good curative effect after hysteroscopy, which can effectively promote the recovery of menstruation, promote the proliferation of endometrium and prevent the re-adhesion of uterine cavity.