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将拉曼光谱法与红外光谱法相结合,以期获得布洛芬更全面的结构信息。另外,为了验证Raman光谱法验证固体分散体的可行性,采用熔融法制备布洛芬固体分散体,并用Raman光谱法和红外光谱法研究其分散性。两种鉴别方法得到一致的结果——布洛芬与载体之间不存在相互作用,以微晶状态分散在固体分散体中,且拉曼光谱法简单易行、快速直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。
Raman spectroscopy combined with infrared spectroscopy in order to obtain more comprehensive structural information of ibuprofen. In addition, in order to verify the feasibility of solid dispersion by Raman spectroscopy, solid dispersion of ibuprofen was prepared by melt method, and its dispersibility was studied by Raman spectroscopy and infrared spectroscopy. The two methods of identification gave consistent results - there was no interaction between ibuprofen and the carrier, dispersed in a solid state dispersion in microcrystalline state, and Raman spectroscopy was simple, fast and direct, without damage to the sample, Is a new and ideal method to check the dispersibility of solid dispersions.