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目的 探讨硒与铅的致突变性及硒的拮抗效应。方法 给予ICR小鼠经口灌胃不同浓度的亚硒酸钠（Na2SeO32.5、5.0和10mg/kg）和醋酸铅[Ph（Ac）2 5、10和25mg/kg],连续3d,进行骨髓嗜多染红细胞微核计数。结果 单纯10mg/kg Na2SeO3、10、25mg/kg Pb（Ac）2组微核率均高于对照（P<0.01）;硒（2.5、5.0和10mg/kg）-铅（10 mg/kg）联合染毒Ⅰ组显示5.0mg/kgNa2SeO3组微核率（2.7‰）低于2.5mg/kgNa2SeO3组（5.0‰）和10mg/kgNa2SeO3组（3.2‰）及单纯10mg/kg Pb（Ac）2组（6.6‰）,P<0.01,但仍高于阴性对照（2.3‰）,P<0.01;硒（2.5、5.0和10mg/kg）-铅（25mg/kg）联合染毒Ⅱ组显示5.0mg/kg Na2SeO3组微核率（2.9‰）低于2.5mg/kgNa2SeO3组（6.4‰）和10mg/kg Na2SeO3组（3.8‰）及单纯25mg/kg Pb（Ac）2组（7.9‰）,P<0.01,但仍高于阴性对照组。结论 硒和铅均具有一定的致突变性,一定量的硒对铅的遗传毒性有拮抗效应。
Objective To investigate the mutagenicity of selenium and lead and the antagonistic effect of selenium. Methods ICR mice were orally administered with different concentrations of sodium selenite (Na2SeO32.5, 5.0 and 10 mg / kg) and lead acetate [Ph (Ac) 2 5, 10 and 25 mg / kg] RBC micronucleus count. Results The micronuclei of 10 mg / kg Na2SeO3, 10, 25 mg / kg Pb (Ac) 2 groups were significantly higher than those of the control (P <0.01) The group Ⅰ showed that the micronucleus rate (2.7 ‰) in the 5.0 mg / kg Na2SeO3 group was lower than that in the 2.5 mg / kg Na2SeO3 group (5.0 ‰) and the 10 mg / kg Na2SeO3 group (3.2 ‰) ‰), P <0.01, but still higher than the negative control (2.3 ‰), P <0.01. The combination of selenium (2.5, 5.0 and 10 mg / kg) The micronucleus rate (2.9 ‰) was lower than 2.5 mg / kg Na2SeO3 group (6.4 ‰) and 10 mg / kg Na2SeO3 group (3.8 ‰) and 25 mg / kg Pb (Ac) Still higher than the negative control group. Conclusion Both selenium and lead have certain mutagenicity. A certain amount of selenium has an antagonistic effect on the genotoxicity of lead.