低氧诱导因子-1(HIF-1)是由两个亚基组成的异源二聚体蛋白,它特异性地与靶基因的低氧反应元件结合,并诱导各种靶基因转录,提高肿瘤细胞的缺氧适应能力,利于其生长、增殖、转移。其机制包括调节肿瘤细胞的代谢、促进肿瘤新生血管形成、抗肿瘤细胞凋亡等。针对HIF-1的治疗可能成为新的辅助抗癌手段。 Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric protein composed of two subunits that specifically binds to hypoxia-responsive elements of the target gene and induces transcription of various target genes and enhances tumor growth Hypoxia cells adapt to its growth, proliferation, metastasis. The mechanisms include the regulation of tumor cell metabolism, promote tumor angiogenesis, anti-tumor cell apoptosis. Treatment targeting HIF-1 may be a new ancillary anticancer agent.