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目的探讨卵巢恶性间皮瘤(OMM)的临床病理学特征、免疫表型、鉴别诊断及预后。方法对1例卵巢恶性间皮瘤的临床资料、病理特点及免疫组化标记进行研究,并复习相关文献。结果患者女性,50岁。全腹CT及妇科彩超示双侧附件区囊实性包块。免疫组化示AE1/AE3、vimentin、EMA、calretinin、mesothelial cell、CK5/6、WT1和D2-40(+),Ki-67阳性率为60%。结论卵巢恶性间皮瘤罕见,临床病理诊断较困难,确诊需结合临床特征、病理形态及免疫表型,且需与腹腔原发或转移的其他肿瘤相鉴别。该肿瘤恶性度高,生存率低,预后较差。
Objective To investigate the clinicopathological characteristics, immunophenotype, differential diagnosis and prognosis of malignant mesothelioma of ovary (OMM). Methods One case of ovarian malignant mesothelioma was studied by clinical data, pathological features and immunohistochemical markers, and the related literatures were reviewed. Results Female patient, 50 years old. Full abdominal CT and gynecological color showed bilateral annex area cystic solid mass. Immunohistochemistry showed that the positive rates of AE1 / AE3, vimentin, EMA, calretinin, mesothelial cells, CK5 / 6, WT1 and D2-40 (+) and Ki-67 were 60%. Conclusions The malignant mesothelioma of ovary is rare and its clinicopathological diagnosis is difficult. The diagnosis of ovarian malignant mesothelioma needs to be combined with clinical features, pathological features and immunophenotypes, and it should be differentiated from other primary or metastatic tumors of the abdominal cavity. The tumor has high malignancy, low survival rate and poor prognosis.