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目的探讨肠道有益菌群联合谷氨酰胺对胃肠癌术后炎症反应、体液免疫功能的影响。方法将80例胃肠癌手术患者随机分成研究组和对照组,研究组41例患者术后在常规治疗的同时应用肠道有益菌群和谷氨酰胺,对照组39例患者术后常规治疗。对两组患者术后炎症反应情况、体液免疫指标及感染性并发症发生率进行对比。结果术后3天白细胞计数和中性粒细胞比例两组间无明显差别,术后8天比较研究组明显低于对照组,C反应蛋白术后3天、8天两组均有显著差异,研究组明显低于对照组。术后IgA、IgM、IgG水平研究组明显高于对照组。术后感染性并发症发生率研究组为9.76%,明显低于对照组的23.08%,差异无统计学意义。结论联合应用肠道有益菌群和谷氨酰胺能够降低胃肠癌术后炎症反应程度,增强体液免疫功能,减少感染性并发症,具有良好的临床应用价值。
Objective To investigate the effect of intestinal beneficial bacteria combined with glutamine on postoperative inflammatory reaction and humoral immune function in patients with gastrointestinal cancer. Methods Eighty patients with gastrointestinal cancer were randomly divided into study group and control group. In the study group, 41 patients received routine beneficial treatment of intestinal flora and glutamine after operation, and 39 patients in control group were treated routinely. The postoperative inflammatory response, humoral immunity index and infectious complication rate were compared between the two groups. Results There was no significant difference between the two groups on the 3rd day after the operation. There was a significant difference between the two groups on the 8th day after the operation in the comparative study group and the control group on the 3rd day and the 8th day after operation. The study group was significantly lower than the control group. Postoperative IgA, IgM, IgG levels in the study group was significantly higher than the control group. The incidence of postoperative infectious complications was 9.76% in the study group, which was significantly lower than that in the control group (23.08%), with no significant difference. Conclusions Combined application of gut microbiota and glutamine can reduce postoperative inflammatory reaction, enhance humoral immune function and reduce infectious complications, which has a good clinical value.