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目的分析促性腺激素释放激素拮抗剂(GnRH-A)方案和促性腺激素释放激素激动剂(GnRH-a)长方案后的胚胎冻融移植(FET)周期的结局,探讨GnRH类似物方案对FET结局的影响。方法回顾性分析2009年1月至12月在本中心采用GnRH-A方案和GnRH-a长方案后的FET周期,比较其妊娠结局。结果 GnRH-A/GnRH-a方案随后的FET周期比较,GnRH-A方案患者年龄较大(33.24 vs.30.12),两组胚胎复苏率(85.57%vs.80%)无差异(P>0.05),临床妊娠率(48.89%vs.42.37%)、种植率(28.57%vs.26.73%)和抱婴回家率(37.78%v.s34.46%)均无显著差异(P>0.05)。FET周期中,妊娠组和未妊娠组相比,临床妊娠组ET胚胎评分显著高于未妊娠组(P<0.05),其余特征均无差异。结论取卵周期GnRH类似物方案对FET周期妊娠结局无明显影响。
Objective To analyze the outcome of embryonic freeze-thaw cycles (FET) after gonadotropin-releasing hormone antagonist (GnRH-A) regimen and gonadotropin-releasing hormone agonist (GnRH-a) regimen and investigate the effect of GnRH analogues on FET The impact of the outcome. Methods The FET cycles of GnRH-A regimen and GnRH-a regimen from January 2009 to December 2009 were retrospectively analyzed to compare the pregnancy outcomes. Results Compared with FET cycles after GnRH-A / GnRH-a regimen, patients in GnRH-A regimen were older (33.24 vs. 30.12) and embryos resuscitation rate (85.57% vs. 80% , Clinical pregnancy rate (48.89% vs.42.37%), implantation rate (28.57% vs.26.73%) and infant pregnancy rate (37.78% v.s34.46%) had no significant difference (P> 0.05). In the FET cycles, the ET embryo scores in clinical pregnancy group were significantly higher than those in non-pregnant group (P <0.05), while other characteristics were not different. Conclusion The GnRH analogues with oocyte retrieval cycle had no significant effect on FET pregnancy outcomes.