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目的探讨心理护理对树突状细胞-细胞因子诱导的杀伤细胞(DC-CIK细胞)免疫治疗恶性肿瘤患者生活质量的影响。方法选取2012年8月至2014年8月间重庆市第三军医大学西南医院收治的116例恶性肿瘤患者,采用随机数字表法分为观察组与对照组,每组58例。所有患者均进行DC-CIK细胞免疫治疗,观察组患者在治疗过程中采用常规护理联合心理护理,对照组患者采用常规护理。比较两组患者心理情况、生活质量及护理满意度情况。结果护理前两组患者心理情况差异无统计学意义(P>0.05);护理后观察组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组,两组比较差异均有统计学意义(均P<0.05)。护理前两组患者生活质量差异无统计学意义(P>0.05);护理后观察组患者生活能力评分(ADL)、生活质量评分(QOL)评分均高于对照组,两组比较差异均有统计学意义(均P<0.05)。护理后对照组与观察组患者护理满意度分别为84.5%与96.6%,两组比较差异有统计学意义(P<0.05)。结论 DC-CIK细胞免疫治疗恶性肿瘤患者采用心理护理效果显著,明显改善患者心理情绪,提高了患者生活质量。
Objective To investigate the effect of psychological nursing on the quality of life of patients with dendritic cells-cytokine-induced killer cells (DC-CIK cells) immunotherapy. Methods A total of 116 patients with malignant tumor admitted to Southwest Hospital of the Third Military Medical University in Chongqing from August 2012 to August 2014 were randomly divided into observation group and control group with 58 cases in each group. All patients were treated with DC-CIK cell immunotherapy. Patients in the observation group received routine nursing combined with psychological nursing while patients in the control group received routine nursing. The psychological condition, quality of life and nursing satisfaction of the two groups were compared. Results There was no significant difference in psychological status between the two groups before nursing (P> 0.05). SAS and SDS scores in the observation group were lower than those in the control group The differences were statistically significant (all P <0.05). There was no significant difference in quality of life between the two groups before nursing (P> 0.05). After nursing, the ADL and QOL scores in the observation group were higher than those in the control group Significance (both P <0.05). After nursing, the nursing satisfaction of the control group and the observation group was 84.5% and 96.6% respectively, with significant difference between the two groups (P <0.05). Conclusion DC-CIK cell immunotherapy of malignant tumor patients with psychological care significantly, significantly improve the patient's emotional and improve patient quality of life.