β-内酰胺类抗生素与氨基糖苷类联合使用的协同作用很易在实验室中观察到.然而氨基糖苷类的毒性是个严重的问题,因为这些抗生素常用于严重的且有肾功能不全的病人以及那些免疫受损以致需延长和反复治疗的病人.在这种情况下,选择的标准是合用二种β-内酰胺抗生素——如抗假单胞菌属的 The synergistic effect of β-lactam antibiotics with aminoglycosides is easily observed in the laboratory, however, the toxicity of aminoglycosides is a serious problem as these antibiotics are commonly used in patients with severe and renal insufficiency and In those cases where immunocompromised patients become prolonged and repeatedly treated, the standard of choice is the combination of two β-lactam antibiotics, such as anti-Pseudomonas