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目的为综合研究神经－内分泌－免疫网络在癫痫发病中的作用，选取γ－氨基丁酸（ＧＡＢＡ）、谷氨酸（ＧＬＵ）、生长抑素（ＳＯＭ）、肿瘤坏死因子（ＴＮＦ）、催乳素（ＰＲＬ）为代表。方法应用高效液相色谱法（ＨＰＬＣ）和放射免疫法（ＲＩＡ）分别检测了上述多种物质在癫痫患者脑脊液（ＣＳＦ）中含量改变，并对其相互关系进行了分析。结果癫痫患者脑脊液中ＧＡＢＡ含量下降，而ＧＬＵ、ＳＯＭ、ＴＮＦ、ＰＲＬ含量均升高。相关分析发现，ＧＡＢＡ与ＧＬＵ及ＳＯＭ之间呈直线负相关，而ＳＯＭ、ＧＬＵ、ＴＮＦ、ＰＲＬ彼此间呈直线正相关。结论ＧＡＢＡ、ＧＬＵ、ＳＯＭ、ＴＮＦ、ＰＲＬ各自都参与了癫痫的发病过程，它们之间的平衡失调可能是癫痫发生的重要原因。
Objective To comprehensively study the role of neuroendocrine-immune network in the pathogenesis of epilepsy, the effects of GABA, GLU, SOM, TNF, Prolactin (PRL) as the representative. Methods The contents of these various substances in cerebrospinal fluid (CSF) of epileptic patients were detected by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA), respectively, and their relationships were analyzed. Results The levels of GABA in cerebrospinal fluid of patients with epilepsy decreased, while the contents of GLU, SOM, TNF and PRL increased. Correlation analysis showed that there was a linear negative correlation between GABA and GLU and SOM, while SOM, GLU, TNF and PRL showed a linear positive correlation with each other. Conclusions GABA, GLU, SOM, TNF and PRL are involved in the pathogenesis of epilepsy. The imbalance between them may be an important cause of epilepsy.