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目的:探讨中西药联合生活方式调整治疗肥胖型多囊卵巢综合征(PCOS)的临床疗效。方法:测定126例肥胖型PCOS的生殖内分泌及一般指标,并与56例无肥胖非PCOS不孕患者进行比较。给予中西药联合生活方式调整治疗6个月,共有100例完成治疗。观察其治疗前后相关指标的变化及随后促排卵情况。结果:126例肥胖型PCOS患者的基础促黄体生成素(LH)、促黄体生成素与卵泡刺激素比值(LH/FSH)、睾酮(T)、体重指数(BMI)、腰臀围比值(WHR)均高于无肥胖非P-COS不孕患者(P<0.05);经多方案治疗后,LH、T、LH/FSH及BMI、WHR均明显下降,差异有统计学意义;卵巢体积减小(P<0.05),排卵率82.26%,妊娠率33.00%。结论:中西药联合生活方式调整治疗肥胖型PCOS,可有效改善其生殖内分泌紊乱,增加促排卵药物的敏感性,提高排卵率及妊娠率,使部分肥胖型PCOS患者恢复排卵和妊娠。
Objective: To explore the clinical curative effect of combined Chinese and Western medicine lifestyle adjustment on obese patients with polycystic ovary syndrome (PCOS). Methods: The reproductive endocrine and general indexes of 126 obese patients with PCOS were determined and compared with 56 non-obese non-obese patients with PCOS. Give Chinese and Western medicine joint lifestyle adjustment and treatment of 6 months, a total of 100 cases to complete the treatment. Observed before and after treatment changes in the relevant indicators and subsequent ovulation induction. Results: The basis of luteinizing hormone (LH), luteinizing hormone and follicle stimulating hormone (LH / FSH), testosterone (T), body mass index (BMI) ) Were significantly higher than those in non-obese non-P-COS infertile women (P <0.05). The LH, T, LH / FSH, BMI and WHR were significantly decreased after treatment with multiple regimens, with significant difference (P <0.05), ovulation rate 82.26%, pregnancy rate 33.00%. Conclusion: The combined lifestyle adjustment of Chinese and Western medicine in the treatment of obese PCOS can effectively improve its reproductive and endocrine disorders, increase the sensitivity of ovulation induction drugs, improve the ovulation rate and pregnancy rate, so that some obese patients with PCOS ovulation and pregnancy recovery.