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目的评价腹腔内热灌注化疗对侵及浆膜的进展期胃癌根治术后预防腹腔复发的疗效。方法进展期胃癌96例,随机分成两组,52例接受术中、术后早期腹腔内热低渗灌注化疗;44例作为对照组接受常温双蒸水冲洗腹腔和 FM 方案静脉化疗。结果治疗组和对照组3年生存率分别为61.5%、45.5%,腹腔复发率分别为5.2%、30%。结论腹腔内热灌注化疗可以预防侵犯浆膜的进展期胃癌术后腹腔复发,是一种安全、有效的治疗手段。
Objective To evaluate the efficacy of intraperitoneal hyperthermic perfusion chemotherapy for prevention of abdominal recurrence after advanced gastric cancer invaded by serous membranes. Methods Ninety-six patients with advanced gastric cancer were randomly divided into two groups. Fifty-two patients received intraperitoneal and hypothermic perfusion chemotherapy during the operation and early postoperative period. Forty-four patients served as control group and received dual-distilled water at room temperature and intraperitoneal chemotherapy with FM regimen. Results The three-year survival rates of the treatment group and the control group were 61.5% and 45.5%, respectively, and the abdominal cavity recurrence rates were 5.2% and 30%, respectively. Conclusion Intraperitoneal hyperthermic perfusion chemotherapy can prevent abdominal cavity recurrence after advanced gastric cancer invasion of the serous membrane. It is a safe and effective treatment.