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[目的]探讨江苏省徐州市铜山区肺癌发病的影响因素,为制定铜山区肺癌防治措施提供科学依据。[方法]在铜山区进行以人群为基础1:1病例对照研究,共调查肺癌病例和健康对照各774例,通过面对面询问的方式填写调查表;采用单因素和多因素非条件Logistic回归分析肺癌影响因素。[结果]单因素非条件Logistic回归分析显示,久居污染企业附近、吸烟、饮酒、近10年家庭变故、老年慢性支气管炎病史、肺结核病史、肿瘤家族史等因素是肺癌发病的危险因素,相应OR值分别为1.99(95%CI:1.44～2.75)、3.20(95%CI:2.58～3.98)、2.18(95%CI:1.56～3.07)、1.58(95%CI:1.12～2.22)、9.04(95%CI:4.10～19.92)、5.05(95%CI:1.10～23.13)、2.03(95%CI:1.27～3.27)。性格开朗是肺癌发病的保护因素,OR值为0.44(95%CI:0.29～0.68)。多因素非条件Logistic回归分析显示,久居污染企业附近、吸烟、老年慢性支气管炎病史、肿瘤家族史等为肺癌发病的主要危险因素,相应OR值分别为1.59(95%CI:1.12～2.25)、3.10(95%CI:2.38～4.04)、6.85(95%CI:3.05～15.40)、1.71(95%CI:1.02～2.85);而性格开朗是肺癌发病的主要保护因素,OR值为0.51(95%CI:0.32～0.81)。[结论]久居污染企业附近、吸烟、老年慢性支气管炎病史、肿瘤家族史增加铜山地区人群的肺癌发病风险,性格开朗则对肺癌发生具有明显保护作用。
[Objective] To investigate the influencing factors of lung cancer incidence in Tongshan District, Xuzhou City, Jiangsu Province, and provide scientific evidence for the development of lung cancer prevention and control measures in Tongshan District. [Method] A population-based 1: 1 case-control study was conducted in Tongshan District. A total of 774 cases of lung cancer cases and healthy controls were surveyed. Questionnaires were filled in by face-to-face interrogation. Univariate and multivariate non-conditional logistic regression analysis was used to analyze lung cancer Influencing factors. [Results] The univariate non-conditional logistic regression analysis showed that smoking, drinking, household accident, elderly chronic bronchitis history, history of tuberculosis and family history of cancer were the risk factors for lung cancer incidence in the vicinity of polluting enterprises for a long time. The corresponding OR Values were 1.99 (95% CI: 1.44-2.75), 3.20 (95% CI: 2.58-3.98), 2.18 (95% CI 1.56-3.07), 1.58 (95% CI 1.12-2.22), 9.04 % CI: 4.10-19.92), 5.05 (95% CI: 1.10-23.13), 2.03 (95% CI: 1.27-3.27). Cheerfulness is a protective factor in the pathogenesis of lung cancer with an OR of 0.44 (95% CI: 0.29-0.68). Multivariate non-conditional logistic regression analysis showed that smoking, chronic bronchitis and family history of cancer were the main risk factors of lung cancer, with corresponding ORs of 1.59 (95% CI: 1.12-2.25) (95% CI: 2.38-4.04), 6.85 (95% CI: 3.05-15.40), and 1.71 (95% CI: 1.02-2.85), respectively; while cheerful personality was the main protective factor in the pathogenesis of lung cancer with OR of 0.51 (95 % CI: 0.32 ~ 0.81). [Conclusion] The smoking history, the history of chronic bronchitis in the elderly and the family history of cancer increased the risk of lung cancer in Tongshan polluted area, and the cheerfulness had a significant protective effect on the occurrence of lung cancer.