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目的:研究银杏叶制剂对大鼠脑缺血再灌注损伤的保护作用。方法:将大鼠随机分为模型组、银杏叶制剂组和伪手术组,每组12只。模型组和银杏叶制剂组的大鼠均采用线栓法制备局灶性脑缺血再灌注损伤的模型,并于尾静脉连续给药3天。检测三组大鼠的脑神经功能损伤程度、脑组织含水量和脑梗死面积。结果:脑缺血再灌注后,伪手术组的大鼠未出现神经功能的损害和梗死灶,模型组的大鼠神经功能缺损症状和梗死区均严重(p<0.05),脑含水量明显高于伪手术组(p<0.05),银杏叶制剂组的大鼠给药3天后神经功能缺损症状、脑组织含水量和脑梗死面积均显著改善(p<0.05)。结论:银杏叶制剂可显著减轻脑水肿,改善大鼠脑缺血再灌注的损伤。
Objective: To study the protective effect of Ginkgo biloba extract on cerebral ischemia-reperfusion injury in rats. Methods: Rats were randomly divided into model group, ginkgo leaf preparation group and sham operation group, 12 in each group. Rats in the model group and the Ginkgo biloba group were treated with a thread embolization method to prepare a model of focal cerebral ischemia-reperfusion injury, and were continuously administered to the tail vein for 3 days. The degree of cerebral nerve function damage, brain tissue water content, and cerebral infarct size were measured in the three groups of rats. RESULTS: After cerebral ischemia-reperfusion, the rats in the sham-operated group did not suffer from neurological impairment and infarction. The neurological deficits and infarction areas in the model group were both severe (p<0.05), and the brain water content was significantly higher. In the sham-operated group (p<0.05), the symptoms of neurological deficits, water content in the brain, and cerebral infarct area were significantly improved in rats in the Ginkgo biloba group after 3 days (p<0.05). Conclusion: Ginkgo biloba extract can significantly reduce cerebral edema and improve cerebral ischemia-reperfusion injury in rats.