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激光加血卟啉衍生物(Hematoporphyrin Derivative,HpD)对治疗表浅癌肿的效果已受到人们的重视,并已用于临床。但激光穿透组织的能力是呈负指数函数衰减的,即使用穿透力较强的6300A氦氖激光,其单束光穿透组织到达2cm深度时,光强也仅为原来的万分之一。因此,激光加HpD对深部肿瘤的疗效很难达到同样的效果。1966年Cohen等曾报道血卟啉(Hematoporphyrin)加X-线治疗小鼠腿部移植瘤的研究结果,作者给小鼠腹腔注射不同剂量的血卟啉后3小时,在植瘤小腿部照射X-线2750伦,发现血卟啉量为0.05mg时,有增加疗效作用。但
The effect of laser plus hematoporphyrin derivative (HpD) on the treatment of superficial cancer has attracted people’s attention and has been used clinically. However, the ability of the laser to penetrate the tissue is attenuated by a negative exponential function. That is, when a 6300A helium neon laser with strong penetrating power is used, when the single beam light penetrates the tissue to a depth of 2 cm, the light intensity is only tens of thousands. one. Therefore, the effect of laser plus HpD on deep tumors is difficult to achieve the same effect. In 1966, Cohen et al. reported the results of Hematoporphyrin plus X-ray treatment of transplanted tumors in mice’s legs. The authors irradiated mice with intraperitoneal injections of different doses of hematoporphyrins for 3 hours, and irradiated them on the shins of tumors. X-ray 2750 lun, found that the amount of hematoporin 0.05mg, there is an increase in efficacy. but