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本文应用环磷酰胺(CTX)及贞芪扶正冲剂(LLAM)在体外观察了对小鼠乳腺肉瘤EMT-6的抑制作用,并与体内治疗结果进行了对比。体外实验发现,LLAM能明显提高荷瘤鼠白细胞的抑瘤能力;体内实验证明,50mg/kg CTX合并LLAM的抑瘤率为79.4%,与单独使用100mg/kgCTX的疗效74.8%相近。提示LLAM有可能通过调节宿主的细胞免疫功能,提高了小鼠的抗瘤能力。
In this paper, the inhibitory effect of cyclophosphamide (CTX) and lanxifuzheng granules (LLAM) on mouse mammary sarcoma EMT-6 was observed in vitro and compared with the in vivo therapeutic results. In vitro experiments showed that LLAM can significantly increase the tumor-bearing capacity of tumor-bearing mice. In vivo experiments demonstrated that the tumor-inhibitory rate of 50 mg/kg CTX combined with LLAM was 79.4%, which was similar to 74.8% of the effect of using 100 mg/kg CTX alone. It is suggested that LLAM may improve the anti-tumor ability of mice by regulating the cellular immune function of the host.