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目的： 探讨卵巢恶性上皮性肿瘤 Ｐ Ｃ Ｎ Ａ 的表达水平与患者病情、预后的关系． 方法： 卵巢恶性上皮性肿瘤石蜡切片进行 Ｐ Ｃ Ｎ Ａ（ Ｐ Ｃ１０） 抗体免疫组化染色． 结果：在 ８４ 例原发性卵巢上皮性肿瘤中，７４ 例 Ｐ Ｃ Ｎ Ａ 呈阳性表达；２０ 例交界性卵巢上皮性肿瘤 Ｐ Ｃ Ｎ Ａ 阳性表达 １３ 例；２３ 例良性卵巢上皮性肿瘤 Ｐ Ｃ Ｎ Ａ 均呈阴性表达；１０ 例正常卵巢组织仅有１ 例呈弱阳性表达． 恶性（ Ｉ Ｒ Ｓ７．２６）、交界性（ Ｉ Ｒ Ｓ３．８５）两组间 Ｐ Ｃ Ｎ Ａ 表达差异十分显著（ Ｐ＜ ０．０１） ；经单因素分析，恶性组内 Ｐ Ｃ Ｎ Ａ 表达（ Ｉ Ｒ Ｓ） 与生存率呈显著负相关（ Ｐ＜ ０．０１）． Ｐ Ｃ Ｎ Ａ表达与肿瘤的临床分期、组织分级和组织类型无关． 结论： Ｐ Ｃ Ｎ Ａ 表达水平的检测可作为判断卵巢恶性上皮性肿瘤患者预后的有价值的指标．
Objective: To investigate the relationship between the expression of P C N A and the prognosis of patients with malignant ovarian tumors. Methods: Immunohistochemical staining of P C N A (P C10) antibody was performed on paraffin sections of ovarian malignant epithelial tumor. Results: Of the 84 cases of primary epithelial ovarian tumors, 74 cases were positive for P C N A, 13 cases were positive for P C N A in 20 cases of borderline ovarian epithelial tumors, and 23 cases were benign ovarian epithelial tumors N A were negative expression; only 10 cases of normal ovarian tissue was weakly positive expression. There were significant differences in P CN A expression between malignant (I R S7.26) and borderline (I R S3.85) groups (P <0.01). Univariate analysis showed that P C N A There was a significant negative correlation between expression (I R S) and survival rate (P <0.01). The expression of P C N A was not related to the clinical stage, histological grade and type of the tumor. Conclusion: The detection of P C N A expression can be used as a valuable index to judge the prognosis of patients with ovarian malignant neoplasm.