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目的探讨三阴性乳腺癌的临床病理特点。方法对2004年6月至2007年12月间本院收治的35例三阴性(TN)乳腺癌患者的临床资料包括发病年龄、月经状态、临床表现、病理类型、组织学分级、淋巴结转移情况、P53表达及病死率进行回顾性分析,并与同期非三阴性(NTN)乳腺癌进行比较。结果与NTN组相比,TN组的患者中位年龄较NTN组年轻(35岁比44岁,P=0.010)且绝经前患者较多(88.5%比67.3%,P=0.010);TN组浸润性导管癌较NTN组多见(91.4%比70.2%,P=0.008),且组织学分级Ⅲ级者较多(43.8%比22.5%,P=0.000);TN组淋巴结转移阳性者较NTN组少(31.8%比64.4%,P=0.000);TN组P53阳性表达率高于NTN组(51.4%比20.7%,P=0.000)。中位随访24个月,两组死亡率差别无统计学意义(P=0.377)。结论三阴性乳腺癌多见于年轻的绝经前妇女,主要病理类型为非特殊类型的高分级浸润性导管癌,淋巴结转移少见,P53阳性表达率较高。
Objective To investigate the clinicopathological features of triple negative breast cancer. Methods The clinical data of 35 cases of triple negative (TN) breast cancer admitted to our hospital from June 2004 to December 2007 included age of onset, menstrual status, clinical manifestations, pathological types, histological grade, lymph node metastasis, P53 expression and mortality were retrospectively analyzed and compared with non-triple negative (NTN) breast cancer over the same period. Results Compared with NTN group, the median age of TN group was significantly younger than that of NTN group (35 vs. 44, P = 0.010) and premenopausal patients (88.5% vs. 67.3%, P = 0.010) The incidence of ductal carcinoma was more common in NTN group than in NTN group (91.4% vs 70.2%, P = 0.008), and histological grade Ⅲ was higher (43.8% vs 22.5%, P = 0.000) (31.8% vs 64.4%, P = 0.000). The positive rate of P53 in TN group was higher than that in NTN group (51.4% vs. 20.7%, P = 0.000). After a median follow-up of 24 months, there was no significant difference in mortality between the two groups (P = 0.377). Conclusion Triple negative breast cancer is more common in young premenopausal women. The main pathological type is non-specific type of high-grade invasive ductal carcinoma. Lymphatic metastasis is rare, and the positive rate of P53 is high.