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本文研究了1-(2,3,4-三-O-苯甲酰-β-D-吡喃木糖基)-偕氨基肟与酸酐及酰氯的缩合反应,探讨了不同缩合剂、不同取代基对环合反应的影响,与酸酐反应可以一步完成,且收率较好;与酰氯反应分两步进行,第一步酰化,第二步脱水环合,芳环上取代基的电性效应,决定环合反应的难易,并证明了该环系的碳苷对酸、碱、热具有化学稳定性,本文合成了12个氧杂二唑类木糖碳苷及2个木糖基化的开环产物,通过光谱及元素分析,确定了它们的结构。
In this paper, the condensation reaction of 1- (2,3,4-tri-O-benzoyl-β-D-xylopyranosyl) -carbamoyloxime with acid anhydride and acid chloride has been studied. The effects of different condensation agents, Base on the cyclization reaction, and the anhydride reaction can be completed in one step, and the yield is good; and the acid chloride reaction in two steps, the first step of acylation, the second dehydration ring, the aromatic ring substituents of the electrical Effect, determine the difficulty of the cyclization reaction, and proved that the ring system of carbon acid on the acid, alkali and heat with chemical stability, synthesis of 12 oxadiazole xylose carbon glycosides and two xylosyl The ring-opened products were identified by spectroscopy and elemental analysis.