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目的:探讨纳洛酮治疗双硫仑样反应的安全性和有效性。方法:将我院54例双硫仑样反应患者随机分为两组,对照组27例予吸气、保护胃黏膜、促进乙醛代谢及对症处理常规治疗;治疗组27例在常规治疗的基础上先予纳洛酮0.8mg静脉推注,继以5%葡萄糖液或木糖醇200mL加纳洛酮(1.2～1.6)mg静脉滴注。结果:治疗组显效23例,有效4例,无效0例;对照组显效5例,有效19例,无效3例。两组比较有显著统计学差异(2=24.35,P<0.01)。结论:纳洛酮治疗双硫仑样反应安全性高,疗效好,值得临床推荐。
Objective: To investigate the safety and efficacy of naloxone in the treatment of disulfiram-like reactions. Methods: 54 cases of disulfiram-like response in our hospital were randomly divided into two groups, the control group of 27 patients were aspirated to protect the gastric mucosa, acetaldehyde metabolism and symptomatic treatment to promote conventional treatment; treatment group of 27 cases based on conventional treatment On the first naloxone 0.8mg intravenous injection, followed by 5% glucose solution or xylitol 200mL ganaloxone (1.2 ~ 1.6) mg intravenous infusion. Results: In the treatment group, 23 cases were markedly effective, 4 cases effective and 0 ineffective. In the control group, 5 cases were markedly effective, 19 cases were effective and 3 cases were ineffective. There was significant difference between the two groups (2 = 24.35, P <0.01). Conclusion: Naloxone treatment of disulfiram-like reaction is safe and effective, it is worth clinical recommendation.