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目的:观察辛伐他汀对慢性阻塞性肺疾病模型大鼠气道炎症和气道黏液高分泌的防治作用及其机制。方法:选用60只雄性健康大鼠制作慢性阻塞性肺疾病大鼠模型。随机分组后,观察组大鼠加用辛伐他汀进行灌胃处理。对比两组大鼠模型在气道炎症和气道黏液分泌指标检出值的差异。结果:观察组大鼠支气管肺泡灌洗液中IL-8、IL-17、以及TNF-α检出值均明显低于对照组(P<0.05)。观察组大鼠黏蛋白5AC、黏蛋白5ACmRN、TLR4、以及TLR4mRNA检出值均明显低于对照组(P<0.05)。结论:用辛伐他汀干预能够减轻慢性阻塞性肺疾病大鼠的病理损害,通过抑制气道炎性因子以及逆转气道黏液高分泌状态,以改善肺功能,发挥临床价值。
Objective: To observe the preventive and therapeutic effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease (COPD) and its mechanism. Methods: Sixty male rats were selected to make chronic obstructive pulmonary disease rat model. After randomization, the rats in the observation group were treated with simvastatin for intragastric administration. The differences between the airway inflammation and airway mucus secretion indexes were compared between the two groups of rats. Results: The levels of IL-8, IL-17 and TNF-α in the bronchoalveolar lavage fluid of the observation group were significantly lower than those of the control group (P <0.05). In the observation group, the expressions of mucin 5AC, mucin 5ACmRN, TLR4 and TLR4 mRNA in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: The intervention with simvastatin can alleviate the pathological damage of chronic obstructive pulmonary disease in rats, which can improve the lung function by inhibiting airway inflammatory cytokines and reversing the airway mucus hypersecretion, and have clinical value.