论文部分内容阅读
目的:探讨左炔诺孕酮宫内缓释系统(LNG-IUS,商品名:曼月乐)治疗子宫腺肌病(adenomyosis,AM)的临床疗效及不良反应。方法:观察58例子宫腺肌病患者LNG-IUS放置前、放置后1个月、3个月、6个月、12个月、18个月、2年的痛经视觉模拟评分法(VAS)评分、月经量、血清CA125、子宫体积和内膜厚度及相关不良反应。结果:LNG-IUS放置后患者痛经明显缓解,VAS评分明显下降,月经量明显减少,子宫内膜变薄,并持续保持疗效,与放置前相比较,差异均有统计学意义(P<0.01);在一定程度上,子宫体积缩小,CA125降低,但差异均无统计学意义(P>0.05)。不良反应主要为阴道少许点滴出血,充分解释后患者多能接受;另有少量脱环、功能性卵巢囊肿、闭经、痤疮等。结论:LNG-IUS是治疗子宫腺肌病的一种有效的保守治疗方法,适合用于痛经和/或月经过多的子宫腺肌病患者。
Objective: To investigate the clinical efficacy and adverse reactions of levonorgestrel-releasing intrauterine system (LNG-IUS, trade name: Mirena) in the treatment of adenomyosis (AM). Methods: Visual analog scale (VAS) score of 58 cases of adenomyosis patients before LNG-IUS placement, 1 month, 3 months, 6 months, 12 months, 18 months and 2 months after placement were observed. , Menstrual volume, serum CA125, uterine volume and intimal thickness and related adverse reactions. Results: After the LNG-IUS was placed, the patients’ dysmenorrhea was significantly relieved, the VAS score was significantly decreased, the menstrual volume was significantly reduced, the endometrium was thinned and the curative effect was maintained. The difference was statistically significant (P <0.01) To a certain extent, the size of the uterus decreased and CA125 decreased, but the difference was not statistically significant (P> 0.05). Adverse reactions mainly vaginal drip a little bit, fully explain the patient to be able to accept; another a small amount of dendritic, functional ovarian cysts, amenorrhea, acne and so on. Conclusion: LNG-IUS is an effective conservative treatment of adenomyosis and is suitable for patients with dysmenorrhea and / or menorrhagia.