趋化因子(chemokines)是一类能够调控细胞定向迁移的细胞因子,广泛存在于白细胞、单核细胞、巨噬细胞、T细胞和B细胞,并且通过与相应的趋化因子受体结合从而介导对白细胞的趋化作用。一种趋化因子能与多个趋化因子受体相结合,而一个趋化因子可能有多个高亲和性受体,它们共同构成复杂的网络系统,在系统性红斑狼疮的发生发展中起到重要作用,本文主要对不同趋化因子及受体与系统性红斑狼疮关系进行综述。 Chemokines are a class of cytokines that regulate the directional migration of cells and are found extensively in leukocytes, monocytes, macrophages, T-cells, and B-cells, and are mediated by binding to the corresponding chemokine receptors Leukocyte chemotaxis. A chemokine binds to multiple chemokine receptors, and a chemokine may have multiple high-affinity receptors that together form a complex network of systems that are under development in the development of systemic lupus erythematosus Play an important role, this article mainly on the different chemokines and receptors and systemic lupus erythematosus relationship.