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目的观察小剂量强的松联合茶碱治疗支气管哮喘的临床效果。方法将90例支气管哮喘患者随机分为A组和B组,各45例。A组与B组分别接受5mg、10mg强的松联合茶碱治疗,并观察1年(至2016年4月30日观察结束)。对比2组患者肺功能、临床症状评分和HPAA功能变化。结果 2组治疗前后FEV1%值、FEV1以及临床症状评分比较差异均无统计学意义(P>0.05)。且治疗后,2组间上述指标比较差异均无统计学意义(P>0.05)。治疗前2组ACTH激发血浆皮质醇浓度、血浆皮质醇基础浓度、血清ACTH水平比较差异无统计学意义(P>0.05)。治疗后,2组ACTH激发血浆皮质醇浓度、血浆皮质醇基础浓度升高,血清ACTH水平降低,差异均有统计学意义(P<0.05)。但治疗后2组间上述指标比较差异均无统计学意义(P>0.05)。结论 5mg与10mg强的松治疗支气管哮喘的疗效相当,可见小剂量(5mg)强的松联合茶碱治疗支气管哮喘疗效好,安全,经济,且对HPAA影响更小,值得临床推广应用。
Objective To observe the clinical efficacy of low-dose prednisone combined with theophylline in the treatment of bronchial asthma. Methods 90 patients with bronchial asthma were randomly divided into group A and group B, 45 cases each. Group A and group B received 5mg, 10mg prednisone and theophylline, and observed for 1 year (until April 30, 2016 the end of observation). The lung function, clinical symptom scores and HPAA function changes in two groups were compared. Results Before and after treatment, FEV 1%, FEV 1 and clinical symptom scores had no significant difference (P> 0.05). After treatment, there was no significant difference between the two groups (P> 0.05). There was no significant difference in ACTH-stimulated plasma cortisol concentration, plasma cortisol concentration and serum ACTH level between the two groups before treatment (P> 0.05). After treatment, ACTH-stimulated plasma cortisol concentration, plasma cortisol concentration and serum ACTH level were significantly lower in both groups (P <0.05). However, there was no significant difference between the two groups after treatment (P> 0.05). Conclusions The efficacy of 5mg and 10mg prednisone in the treatment of bronchial asthma is comparable. It can be seen that low dose (5mg) prednisone combined with theophylline is effective, safe and economical in the treatment of bronchial asthma, and has less impact on HPAA, which is worthy of clinical application.