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采用免疫细胞化学方法探讨胃粘膜内 CD3+细胞 ,S- 10 0 +树突状细胞和 n NOS的表达与慢性胃炎的关系及意义。检测标本均取自胃窦部活检的胃粘膜组织。结果显示 CD3+细胞主要分布于粘膜上皮、腺上皮和固有膜内 ,而 S- 10 0 +树突状细胞则主要位于固有膜内 ,正常组与浅表性胃炎组和萎缩性胃炎组 ,浅表性胃炎组与萎缩性胃炎组细胞数量有显著性差异(P<0 .0 1) ,n NOS阳性反应主要位于粘膜上皮和腺上皮的基底部 ,但各组之间 n NOS的表达程度不同 ,特别是萎缩性胃炎与浅表性胃炎有显著性差异 (P<0 .0 1) ,我们认为 ,对 CD3+细胞 ,S- 10 0 +树突状细胞和 n NOS的检测 ,不仅有助于判断胃炎的病变程度和临床疗效 ,而且也为胃炎的治疗提供新的启示
The relationship between the expression of CD10 + cells, S-100 + dendritic cells and nNOS in gastric mucosa and chronic gastritis and their significance were explored by immunocytochemistry. Test specimens were taken from the gastric mucosa of gastric biopsy. The results showed that CD3 + cells mainly distributed in the mucosal epithelium, glandular epithelium and lamina propria, while the S-10 0 + dendritic cells were mainly located in the lamina propria, the normal group and the superficial gastritis group and the atrophic gastritis group, superficial The numbers of cells in gastritis group and atrophic gastritis group were significantly different (P <0.01). The positive reaction of nOS in nostril was mainly located in the basal part of mucosal epithelium and glandular epithelium, but the expression of nNOS in each group was different, In particular, there was a significant difference between atrophic gastritis and superficial gastritis (P <0.01). In our opinion, the detection of S-100 + dendritic cells and nNOS in CD3 + cells not only helps to judge Gastritis lesions and clinical efficacy, but also for the treatment of gastritis provide new insights