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Mimecan属亮氨酸富集蛋白家族(small leucine-rich proteoglycan,SLRP),有3种亚型:osteoglycin,keratan sulfate glycoprotein和mimecan,在人类的多种组织中表达,具有重要的生理病理功能。Mimecan在胶原纤维的生成、细胞生长、分化和迁移过程中发挥着重要作用,与纤维化疾病和骨疾病关系密切。此外,mimecan在结直肠肿瘤、垂体瘤和肝癌等恶性肿瘤中的表达与正常组织不同,提示其可能与这些肿瘤的发生有关。
Mimecan is a small leucine-rich proteoglycan (SLRP) with three subtypes: osteoglycin, keratan sulfate glycoprotein and mimecan, which are expressed in many human tissues and have important physiological and pathological functions. Mimecan plays an important role in the formation of collagen fibers, cell growth, differentiation and migration, and is closely related to fibrosis and bone diseases. In addition, the expression of mimecan in colorectal tumors, pituitary tumors and liver cancer and other malignant tumors and normal tissues, suggesting that it may be related to the occurrence of these tumors.