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目的:探讨生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的临床效果及对血清炎性因子的影响。方法:选取2013年2月—2015年2月来滨州市中医医院就诊的2型糖尿病患者152例,采用随机数字法分为观察组77例和对照组75例。对照组给予格列美脲进行治疗,观察组在对照组治疗的基础上联合生脉注射液治疗。观察比较两组患者的临床有效率,空腹血糖(FBG),餐后2 h血糖(2 h PBG),糖化血红蛋白(Hb A1c)的改变及血清高敏C反应蛋白(hs-CRP),肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL~(-1)β)水平变化及不良反应情况。结果:观察组总有效率92.21%,明显高于对照组的78.67%(P<0.05)。两组FBG[(5.87±0.32)VS(10.63±0.53)mmol·L~(-1)],2 h PBG[(6.52±1.22)VS(11.24±2.72)mmol·L~(-1)],Hb A1c[(4.42±0.37)%VS(6.21±0.52)%]比较,观察组明显低于对照组(P<0.05)。治疗后,两组患者的hs-CRP,TNF-α,IL~(-1)β水平显著降低(P<0.05),且两组hs-CRP[(2.25±0.73)VS(3.37±1.01)g·L~(-1)],TNF-α[(1.56±0.47)VS(2.23±0.44)ng·L~(-1)],IL~(-1)β[(15.36±3.70)VS(22.94±3.81)ng·L~(-1)]比较,观察组水平明显低于对照组(P<0.05)。两组患者治疗期间不良反应主要为呕吐、腹泻和低血糖,经对症治疗后均痊愈,不良反应发生率比较差异无统计学意义。结论:生脉注射液联合格列美脲治疗气阴两虚型2型糖尿病的疗效明显,同时可降低患者体内炎性因子的水平,从而可能延缓气阴两虚型2型糖尿病并发症的发生,值得临床推广使用。
Objective: To investigate the clinical effects of Shengmai injection combined with glimepiride in treating type 2 diabetes of qi-yin-deficiency syndrome and its effect on serum inflammatory factors. Methods: A total of 152 type 2 diabetic patients who came to Binzhou Chinese Medicine Hospital from February 2013 to February 2015 were randomly divided into observation group (n = 77) and control group (n = 75). The control group was treated with glimepiride. The observation group was treated with Shengmai Injection on the basis of the control group. The clinical efficacy, fasting blood glucose (FBG), 2-hour postprandial blood glucose (2 h PBG), HbA1c changes, serum hs-CRP, tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) levels and adverse reactions. Results: The total effective rate in the observation group was 92.21%, which was significantly higher than that in the control group (78.67%, P <0.05). Two groups of FBG [(5.87 ± 0.32) VS (10.63 ± 0.53) mmol·L -1] and 2 h PBG [(6.52 ± 1.22) VS (11.24 ± 2.72) mmol·L -1] Hb A1c [(4.42 ± 0.37)% VS (6.21 ± 0.52)%], the observation group was significantly lower than the control group (P <0.05). After treatment, the levels of hs-CRP, TNF-α and IL-1β were significantly decreased in both groups (P <0.05), and the hs-CRP levels in the two groups were significantly higher than those in the control group (2.25 ± 0.73 vs 3.37 ± 1.01 g (-1.56 ± 0.47) VS (2.23 ± 0.44) ng · L -1], IL -1β [(15.36 ± 3.70) VS (22.94 ± 3.81 ng · L -1], the level of the observation group was significantly lower than that of the control group (P <0.05). The two groups of patients during treatment of adverse reactions are mainly vomiting, diarrhea and hypoglycemia, after symptomatic treatment were cured, the incidence of adverse reactions was no significant difference. Conclusion: Shengmai injection combined with glimepiride in the treatment of type 2 diabetes with deficiency of both qi and yin has obvious curative effect and can reduce the level of inflammatory cytokines in patients, which may delay the occurrence of type 2 diabetes complications of qi and yin deficiency. , It is worth to promote clinical use.