广谱抗真菌药氟康唑(FCZ)为一种双三唑类衍生物,它在健康人体内药代动力学研究较多。口服后吸收良好,生物利用度大于90%。血药半衰期为30h,服药1周后血药浓度达稳态,约为单次剂量的2.5倍。吸收后药物迅速扩散入组织和体液(包括脑脊液)。体内代谢较少。主要经尿以原型排泄。口服抗真菌剂及其它治疗皮肤病药物后其在皮肤中的分布很重要,但迄今研究很少。报告健康男性志愿者每日1次口服50mg FCZ 胶囊12天及每周1次口服150mg 2周后,血清、角质层、去角质层的表皮-真皮和汗液中的药物浓 Broad-spectrum antifungal fluconazole (FCZ) is a biotriazole derivative that has been studied for pharmacokinetics in healthy volunteers. After oral absorption, bioavailability greater than 90%. Blood half-life of 30h, 1 week after taking blood drug concentration reached steady state, about 2.5 times the single dose. After absorption, the drug rapidly diffuses into the tissues and body fluids (including cerebrospinal fluid). Less metabolism in the body. The main excretion of urine by the prototype. Oral antifungal agents and other treatments for dermatological skin distribution are important, but to date few studies have been done. Report healthy male volunteers once daily oral administration of 50mg FCZ capsules 12 days and once weekly 150mg 2 weeks after the serum, the stratum corneum, exfoliation of the epidermis - dermal and sweat drug concentration