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本文报道了126例红斑狼疮(SLE)患者及19例其它胶原疾病患者的NK活性,用LDH释放测定法发现SLE患者NK活性为12.01±8.03%,对照组为32.45±8.17%(P<0.001)。9例类风关的NK活性也低(P<0.001),绝大多数SLE患者的NK活性比正常人的NK活性均值低,仅2例轻型患者(1.59%)的NK活性超过正常人均值。16例具有肾脏损害的SLE患者NK活性更低(7.11±5.11%),20例未用激素治疗的NK活性同样受到损害(13.43±10.99%)。说明SLE患者的NK功能受损,也反映了NK活性与疾病的严重与否有关。
The NK activity in 126 patients with lupus erythematosus (SLE) and 19 patients with other collagen diseases was reported in this paper. The LDH release assay showed that NK activity was 12.01 ± 8.03% in SLE patients and 32.45 ± 8.17% in control patients (P <0.001) . The NK activity was also lower in the nine cases (P <0.001). The NK activity of the majority of patients with SLE was lower than that of normal people. NK activity in two patients with mild type (1.59%) was higher than the normal average. Twenty-six patients with SLE with renal impairment had lower NK activity (7.11 ± 5.11%), and 20 patients without hormone treatment also had an impaired NK activity (13.43 ± 10.99%). That SLE patients with impaired NK function, but also reflects the NK activity and the severity of the disease or not.