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本文采用垂直平板梯度电泳法对71例原发性肝癌(PHC)和84例其他疾病进行γ-谷氨酰转肽酶同功酶Ⅱ(GGTⅡ)的检测,同时对照甲胎蛋白(AFP)和血清γ-谷氨酰转肽酶(GGT)活力。结果:PHC组GGTⅡ阳性率显著高于肝脏良性疾病组及转移性肝癌组;不同AFP含量组GGTⅡ阳性率间无显著差异;GGTⅡ阳性率与血清总GGT活力也无相应的平行关系。提示:GGTⅡ对PHC具有诊断意义,可作为AFP试验的重要补充;对血清总GGT不升高的可疑病例,同样具有检测意义。
In this study, 71 cases of primary liver cancer (PHC) and 84 cases of other diseases were tested for gamma-glutamyl transpeptidase isoenzyme II (GGTII) by vertical plate gradient electrophoresis. Serum gamma-glutamyl transpeptidase (GGT) activity. RESULTS: The positive rate of GGTII in PHC group was significantly higher than that in benign liver disease group and metastatic liver cancer group. There was no significant difference in GGTII positive rate between different AFP content groups. There was no corresponding parallel relationship between GGTII positive rate and serum total GGT activity. Hint: GGTII has diagnostic significance for PHC and can be used as an important supplement to AFP test; it also has significance for detecting suspicious cases in which serum total GGT does not increase.