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目的探讨无创正压通气联合间断雾化吸入可比特对重症支气管哮喘患者呼出气一氧化氮(FeNO)和血清超敏C反应蛋白(Hs-CRP)的影响。方法 60例重症支气管哮喘患者随机分为两组,对照组和治疗组;对照组30例,治疗组30例。对照组采用常规治疗,治疗组在常规治疗的基础上加用无创正压通气联合间断雾化吸入可比特。比较治疗后呼吸功能、FeNO和血清hs-CRP。结果治疗后两组的呼吸功能均明显改善,并且治疗组改善更明显(P<0.05)。两组治疗后FeNO和hs-CRP均明显降低,但治疗组降低更明显(P<0.05),具有统计学意义。结论无创正压通气联合间断雾化吸入可比特明显减轻重症支气管哮喘患者的炎症状态,改善病情。
Objective To investigate the effects of non-invasive positive pressure ventilation combined with intermittent inhalation of cortisol on exhaled nitric oxide (FeNO) and serum high sensitive C-reactive protein (Hs-CRP) in patients with severe bronchial asthma. Methods Sixty patients with severe bronchial asthma were randomly divided into two groups: the control group and the treatment group; the control group, 30 patients and the treatment group, 30 patients. The control group was treated by conventional therapy. The treatment group received non-invasive positive pressure ventilation combined with intermittent inhalation based on routine treatment. Respiratory function, FeNO and serum hs-CRP were compared after treatment. Results After treatment, the respiratory function of both groups was significantly improved, and the treatment group improved more significantly (P <0.05). After treatment, FeNO and hs-CRP were significantly lower in both groups, but the treatment group decreased more significantly (P <0.05), with statistical significance. Conclusions Noninvasive positive pressure ventilation combined with inhalation of intermittent inhalation can significantly reduce the inflammatory state and improve the condition of patients with severe bronchial asthma.