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头孢吡肟(cefepime,Ⅰ)为新的可供注射用广谱头孢菌素,通常与L-精氨酸(Ⅱ)配伍,每瓶含Ⅰ1g,Ⅱ0.72g.本文推荐用二阶导数分光光度法测定注射剂中的Ⅰ和Ⅱ.方法简便、快速,检测限低,且准确度、精密度好.将Ⅰ和Ⅱ配制成0.5和0.36mg·ml~(-1)的水溶液,并稀释成系列工作标准液,各为5～50和3.6～36μrn·ml~(-1).用Shimadzu UV_(240)双光束分光光度计(导数波长差为4nm)进行测定.
Cefepime (Ⅰ) is a new broad-spectrum cephalosporin for injection and is usually compatible with L-arginine (Ⅱ), and each bottle contains Ⅰ1g and Ⅱ0.72g. In this paper, the second derivative spectrophotometry The method is simple and rapid, the detection limit is low, and the precision and precision are good.I and Ⅱ are prepared into 0.5 and 0.36 mg · ml -1 aqueous solution and diluted into series Working standards, each 5 to 50 and 3.6 to 36 μrn · ml -1, were measured using a Shimadzu UV 240 spectrophotometer (with a derivative wavelength difference of 4 nm).