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目的:观察石英毓麟汤辅助治疗多囊卵巢综合症(PCOS)的临床疗效及对血清瘦素(Leptin)水平的影响。方法:将海南省中医院2012年3月~2015年3月收治的94例PCOS患者采用随机数字表法分为观察组和对照组各47例,两组均给予西医常规治疗(达英-35、氯米芬、尿促性素等),观察组加用石英毓麟汤辅助治疗3个月经周期,比较两组疗效。结果:治疗后观察组血清LH、T、E_2水平改善优于对照组(P<0.05),中医证候各项积分及总分显著低于对照组(P<0.05),卵巢体积显著小于对照组(P<0.05),子宫体积显著大于对照组(P<0.05),血清瘦素水平显著低于对照组(P<0.05),痊愈率显著高于对照组(P<0.05)。结论:石英毓麟汤辅助治疗PCOS对于改善患者的临床证候、降低瘦素水平、改善激素水平及提高治疗效果具有积极作用。
Objective: To observe the clinical efficacy of Shi Yu Yulin Decoction in the treatment of polycystic ovary syndrome (PCOS) and its effect on serum leptin level. Methods: A total of 94 PCOS patients admitted to Hainan Provincial Hospital of Traditional Chinese Medicine from March 2012 to March 2015 were randomly divided into observation group (n = 47) and control group (n = 47), and the two groups were given conventional western medicine , Clomiphene, urinary gonadotropin, etc.), the observation group plus quartz Yulin Teng adjuvant treatment of three menstrual cycles, the two groups were compared. Results: After treatment, the levels of serum LH, T and E 2 in observation group were better than those in control group (P <0.05). The integrals and total scores of syndromes in TCM were significantly lower than those in control group (P <0.05) (P <0.05). The uterine volume was significantly larger than that of the control group (P <0.05). The serum leptin level was significantly lower than that of the control group (P <0.05). The cure rate was significantly higher than that of the control group (P <0.05). Conclusion: The adjuvant treatment of PCY with quartz Yulin Decoction has a positive effect on improving the clinical syndromes, lowering the leptin level, improving the hormone level and improving the therapeutic effect.