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目的 对奥美拉唑和西咪替丁对十二指肠溃疡病愈合率和复发率影响的对比研究。方法５３ 例经内镜检查证实的活动性十二指肠溃疡病，随机分成奥美拉唑组和西咪替丁组，先行短程治疗。奥美拉唑每日１ 次，每次２０ｍｇ，治疗４ 周；西咪替丁每次８００ｍｇ，每晚睡前服，治疗４～６ 周。结果 奥美拉唑组和西咪替丁组４ 周溃疡愈合率分别为９２．３ ％（２４／２６ 例） 和６６ ．７％ （１８／２７ 例），西咪替丁组６ 周溃疡愈合率为８５．２％ （２３／２７ 例）。对溃疡愈合的４７ 例进行长程治疗，前者用量是一次口服２０ｍｇ，每周２次；后者是４００ｍｇ，每晚睡前服一次；各用药一年，观察一年内溃疡累积复发率。复发均经内镜检查证实。奥美拉唑组一年内累积复发率为４．２％ （１／２４），西咪替丁组为２６．１％ （６／２３）。结论 推测奥美拉唑组短程治疗时溃疡愈合率高于西咪替丁组而长程治疗时一年累积复发率明显低于西咪替丁组，是奥美拉唑对酸抑制程度强和２４ 小时内抑制酸分泌的持续时间长的缘故。
Objective To compare the effects of omeprazole and cimetidine on healing rate and recurrence rate of duodenal ulcer disease. Methods Fifty-three patients with active duodenal ulcer confirmed by endoscopy were randomly divided into omeprazole group and cimetidine group. Omeprazole once daily, each 20mg, for 4 weeks; cimetidine 800mg each time, before going to bed every night, treatment for 4 to 6 weeks. Results The ulcer healing rates of omeprazole group and cimetidine group for 4 weeks were 92.3% (24/26 cases) and 66 cases respectively. 7% (18/27 cases). The healing rate of ulcer in cimetidine group for 6 weeks was 85.2% (23/27 cases). 47 cases of ulcer healing for long-term treatment, the former dosage is an oral 20mg, 2 times a week; the latter is 400mg, every night before bedtime; each medication for one year to observe the cumulative recurrence rate of ulcers within a year. Recurrence were confirmed by endoscopy. The omeprazole group had a cumulative recurrence rate of 4.2% (1/24) in one year and 26.1% (6/23) in the cimetidine group. Conclusions The ulcer healing rate in omeprazole group is higher than that in cimetidine group and the one-year cumulative recurrence rate in omeprazole group is significantly lower than that in cimetidine group, Inhibition of acid secretion in the long duration of reason.