论文部分内容阅读
10多年前,阿霉素、柔红霉素首次用于临床以来,经广泛深入研究,已成为治疗急性白血病、非何杰金淋巴瘤、乳癌、何杰金氏病和肉瘤的重要药物,但它有心肌损害、骨髓抑制、脱发以及胃肠道反应等,使其应用受到限制,并促进了合成或寻找低毒的蒽环类新药。但目前仍以阿霉素和柔红霉素为常用。本文简要介绍此类药物的国外研究近况。 重要蒽环类 1.阿霉素(14-羟柔红霉素;adriamycin;doxorubicin)属于糖甙类抗生素,由strep-tomyces peucitus发酵液中提取。与柔红霉素的区别是14-C位上有OH基。阿霉素分
More than 10 years ago, doxorubicin and daunorubicin have become the most important drugs for the treatment of acute leukemia, non-Hodgkin’s lymphoma, breast cancer, Hodgkin’s disease and sarcoma since their first clinical application. It has myocardial damage, myelosuppression, hair loss and gastrointestinal reactions, its application is limited, and to promote the synthesis or search for low toxicity anthracycline drugs. However, adriamycin and daunorubicin are still commonly used. This article briefly describes the current status of such studies abroad. Important Anthracyclines 1. Adriamycin (adriamycin; doxorubicin) is a glycoside antibiotic that is extracted from the fermentation broth of strep-tomyces peucitus. The difference from daunorubicin is the OH group at the 14-C position. Adriamycin points