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目的了解儿童神经母细胞瘤骨转移在核素全身骨显像中的特点以及核素全身骨显像在诊断儿童神经母细胞瘤骨转移中的临床应用价值。方法对300例确诊为神经母细胞瘤的患儿全身骨显像结果进行分析,并与成人骨转移癌进行比较。结果 (1)儿童神经母细胞瘤骨转移阳性率为24%;(2)儿童神经母细胞瘤骨转移常见于长骨干骺端,并呈对称性分布;(3)骨转移灶放射性浓聚较浅淡;(4)<10个转移灶者占总数的82%,转移部位以四肢骨多见占46.83%,其中股骨最常见,为23.4%。结论儿童神经母细胞瘤骨转移在核素全身骨显像中有独特的特点,核素全身骨显像对儿童神经母细胞瘤骨转移的诊断,有重要临床意义。
Objective To investigate the characteristics of bone metastasis in children with neuroblastoma in radionuclide whole body bone imaging and the clinical value of radionuclide bone imaging in the diagnosis of bone metastasis in children with neuroblastoma. Methods The results of whole body bone imaging in 300 children with neuroblastoma were analyzed and compared with that of adult bone metastases. Results (1) The positive rate of bone metastasis in children with neuroblastoma was 24%. (2) Bone metastasis in children with neuroblastoma was common in the metaphysis of the long bones and showed a symmetrical distribution. (3) Shallow; (4) <10 metastases accounted for 82% of the total number of metastatic sites to limb extremity accounted for 46.83%, of which the most common femur was 23.4%. Conclusion Bone metastasis of neuroblastoma in children has unique characteristics in radionuclide bone imaging. Radionuclide bone scintigraphy has important clinical significance in diagnosis of bone metastasis of neuroblastoma in children.