肾上腺素是治疗心脏停搏的有效药物。目前对儿童所用标准剂量(SDE)为0.01mg/kg。作者连续对20例各种原因心脏停搏儿童至少给予2次SDE静注后不能恢复自动循环(ROSC)者,再过5分钟后给予大剂量肾上腺素(HDE)0.2mg/kg,婴幼儿稀释成1:10000,较大儿童为1:1000。对心动过缓及心脏停跳者另给阿托品。此外还给予重碳酸钠及纯氧等。将先前20例只接受2次以上SDE者作为对照,观察结果。其他复苏方案相同两组的年龄,停搏期间加压药使用时间的比率,原先已接受CPR的比例,从停搏到CPR开始或第一次肾上腺素使用的时间均无显著差别。 结果:HDE组中14例在给药后5分钟内出现ROSC,对照组无一例出现(P<0.001)。该14例 Epinephrine is a potent drug for cardiac arrest. The current standard dose for children (SDE) is 0.01 mg / kg. The authors consecutively administered 20 patients with cardiac arrest for at least 2 cycles of SDE without automatic circulation (ROSC), and then given a high dose of HDE 0.2 mg / kg 5 minutes later, infants and young children were diluted At 1: 10000, the older child is 1: 1000. Atropine for bradycardia and cardiac arrest. In addition to give sodium bicarbonate and pure oxygen. The previous 20 cases received only 2 times more than SDE as a control, the results were observed. There was no significant difference in age between the same two arms of the other resuscitation regimens, the duration of pressured drug use during the arrest, the proportion of CPR that had previously been accepted, or the time from arrest to CPR or first adrenaline use. Results: In HDE group, 14 cases showed ROSC within 5 minutes after administration, and none in control group (P <0.001). The 14 cases