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目的研究复合加巴喷丁与盐酸羟考酮对老年糖尿病性神经痛治疗的效果及不良反应。方法选择鹿邑县人民医院自2014年1月至2016年1月就诊的老年糖尿病神经痛患者152例为研究对象,随机分成治疗组与对照组,对照组给予盐酸羟考酮控释片进行治疗,治疗组给予盐酸羟考酮控释片复合加巴喷丁进行治疗。对比两组患者的不良反应发生率以及治疗前与治疗25 d后的疼痛强度评分、生活质量评分。结果治疗组治疗25 d的疼痛强度评分、生活质量评分明显低于对照组;治疗组的不良反应发生率低于对照组,对比以上指标,差异有统计学意义(P<0.05)。结论对老年糖尿病神经痛患者采用盐酸羟考酮控释片复合加巴喷丁进行治疗能够改善患者生活质量以及神经疼痛症状,并且药物使用的不良反应较少。
Objective To study the effects and adverse reactions of combination of gabapentin and oxycodone hydrochloride on senile diabetic neuropathic pain. Methods 152 patients with senile diabetic neuropathic pain who were treated in Luyi People’s Hospital from January 2014 to January 2016 were selected and divided into treatment group and control group randomly. The control group was given oxycodone hydrochloride controlled-release tablets , The treatment group was given oxycodone hydrochloride controlled-release tablets combined with gabapentin for treatment. The incidence of adverse reactions and the scores of pain intensity and quality of life before and 25 days after treatment were compared between the two groups. Results The pain intensity score and quality of life score of the treatment group on the 25th day after treatment were significantly lower than those of the control group. The incidence of adverse reactions in the treatment group was lower than that of the control group. The difference was statistically significant (P <0.05). Conclusion The treatment of elderly diabetic patients with neuropathic pain with oxycodone hydrochloride and gabapentin can improve the quality of life and neuropathic pain in patients with less adverse drug reactions.