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目的侵及浆膜或浆膜外的胃肠道癌根治术后致死的主要原因是肿瘤的局部复发与它处转移。本临床研究探讨术后腹腔内低渗、高温灌注化疗在防治术后复发与转移的作用。方法对我院5年期间行手术治疗的进展期胃肠道癌患者317例分为2组,1组行术后腹腔低渗高温灌注化疗,另1组行术后单纯静脉化疗,对其临床效果与预后进行对照观察。结果腹腔组1、3、5年存活率为92%、72%、58%,对照组为81%、57%、38%,5年存活率比较P<0·01。结论腹腔化疗组因其综合应用了区域化疗、热疗和大容量液体对腹腔机械灌洗作用,通过清除和杀灭术后腹腔游离癌细胞和微小病灶,有效防治了术后复发和肝转移。
Purpose The main cause of death after radical surgery of gastrointestinal cancer outside the serosal or serosa is the local recurrence of the tumor and its metastasis. The clinical study of postoperative intraperitoneal hypotonic, high temperature perfusion chemotherapy in the prevention and treatment of recurrence and metastasis. Methods A total of 317 patients with advanced gastrointestinal cancer undergoing surgery for 5 years in our hospital were divided into two groups. Group 1 received postoperative intraperitoneal hyperthermic perfusion chemotherapy and another group received postoperative intravenous chemotherapy. Control effect and prognosis. Results The 1, 3, 5-year survival rates in the abdominal cavity group were 92%, 72% and 58%, respectively. The control group was 81%, 57% and 38%. The 5-year survival rate was P <0.01. Conclusion Intraperitoneal chemotherapy can effectively prevent and treat postoperative recurrence and liver metastasis by removing and killing the postoperative peritoneal free cancer cells and micro-lesions because of the combined application of regional chemotherapy, hyperthermia and large volume liquid to abdominal peritoneal lavage.