人IgA1分子是IgA肾病中沉积于肾小球系膜区的主要亚型。IgA1的独特结构是其粘蛋白型的绞链区和绞链区上的O 聚糖。当O 聚糖出现异常 ,使IgA1通过相互聚合形成多聚体 ,诱发机体产生自身抗体 ,与系膜细胞及细胞外基质结合增多等不同途径和机制沉积于肾小球系膜区 ,可能参与了部分IgA肾病的发病 Human IgA1 molecules are the major subtype deposited in the glomerular mesangial area in IgA nephropathy. The unique structure of IgA1 is its mucinous hinge region and the O-glycans on the hinge region. When O-glycans are abnormal, IgA1 may accumulate in the glomerular mesangial area through various mechanisms such as the formation of multimers via polymerization, the induction of autoantibodies in the body, and the increased binding to mesangial cells and extracellular matrix, possibly involved Part IgA nephropathy