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目的探讨糖尿病肾病患者糖化血红蛋白与尿酸检测的临床意义。方法 50例糖尿病肾病患者作为实验A组,50例无肾病的糖尿病患者作为实验B组,50例健康人作为对照组,分别测定三组空腹血糖、糖化血红蛋白、尿酸、血肌酐并进行比较。结果实验A组、实验B组的糖化血红蛋白、尿酸、空腹血糖均显著高于对照组(P<0.05);实验A组的糖化血红蛋白、尿酸、血肌酐水平均显著高于实验B组(P<0.05);实验A组血肌酐高于对照组(P<0.05)。实验A组中肾功能失代偿者的糖化血红蛋白、尿酸、血肌酐水平明显高于肾功能代偿者(P<0.05)。结论糖化血红蛋白和尿酸水平与糖尿病肾病显著相关,对预测糖尿病肾病患者的肾脏损害程度有重要的临床意义。
Objective To investigate the clinical significance of detecting glycated hemoglobin and uric acid in patients with diabetic nephropathy. Methods Fifty patients with diabetic nephropathy as experimental group A, 50 patients with nephropathy without diabetes as experimental group B and 50 healthy people as control group were measured for fasting blood glucose, glycosylated hemoglobin, uric acid and serum creatinine and compared. Results The levels of HbA1c, uric acid and fasting blood glucose in experimental group A and B were significantly higher than those in control group (P <0.05). The levels of HbA1c, uric acid and serum creatinine in experimental group A were significantly higher than those in experimental group B (P < 0.05). The serum creatinine in experimental group A was higher than that in control group (P <0.05). In the experimental group A, the levels of HbA1c, uric acid and serum creatinine were significantly higher in those with decompensated renal function (P <0.05). Conclusions The levels of HbA1c and uric acid are significantly correlated with diabetic nephropathy and have important clinical significance in predicting the degree of renal damage in patients with diabetic nephropathy.