噻唑烷二酮类药物作为过氧化物酶体增殖物激活受体-γ激动剂,能够增加胰岛素敏感性,减轻胰岛素抵抗,有着显著的降糖作用。越来越多的证据表明,噻唑烷二酮对心血管系统也发挥着影响。一方面,在调节血压,血脂代谢,氧化应激,抗炎,纤溶活性与抗凝等方面对心血管起到保护作用。另一方面,在增加体重,导致水肿和水钠潴留以及加重心衰等方面对心血管产生不利的影响。本文就噻唑烷二酮对心血管系统的影响做一综述。 Thiazolidinediones as peroxisome proliferator-activated receptor-gamma agonists, can increase insulin sensitivity, reduce insulin resistance, has a significant hypoglycemic effect. There is growing evidence that thiazolidinediones also exert an influence on the cardiovascular system. On the one hand, it plays a protective role in the regulation of blood pressure, lipid metabolism, oxidative stress, anti-inflammatory, fibrinolytic activity and anticoagulation. On the other hand, it has adverse effects on cardiovascular in terms of increasing body weight, causing edema, water and sodium retention, and aggravating heart failure. This article reviews the effects of thiazolidinediones on the cardiovascular system.