论文部分内容阅读
大量的临床和流行病学研究已证实,相当一部分急、慢性肝炎和肝硬变是 HBV 感染的结果;慢性 HBV 感染与肝癌的发生也有某种联系。最近进行的肝组织中 HBsAg 和DNA 检测进一步证实,某些 HBsAg 阴性的慢性肝病,包括肝细胞癌在内,也可能与HBV 感染有关。本研究以血清 HBsAg 阴性的慢性肝病患者为对象,应用杂交技术测其血清和肝细胞中的 HBV DNA 片段,并对检测结果作出分析。将研究分成两组:观察组134(男83,女51)例,年龄为18～72岁,其中慢性活动性肝炎105(肝硬变33)例,慢性迁延性肝炎8例,
A large number of clinical and epidemiological studies have confirmed that a considerable number of acute and chronic hepatitis and cirrhosis are the result of HBV infection. Chronic HBV infection also has some connection with the occurrence of liver cancer. Recent tests of HBsAg and DNA in liver tissue further confirm that some HBsAg-negative chronic liver diseases, including hepatocellular carcinoma, may also be associated with HBV infection. In this study, serum HBsAg-negative patients with chronic liver disease as the object, the application of hybridization to measure HBV DNA fragments in serum and hepatocytes, and the test results were analyzed. The study was divided into two groups: observation group 134 (male 83, female 51), aged 18 to 72 years, of which chronic active hepatitis 105 (cirrhosis 33), chronic persistent hepatitis 8 cases,