作者研究了25例DLE口腔病损活检,HE染色的标本,并提出仅用口腔粘膜病损的活检标本即可对DLE作出诊断的观点。作者发现,在这些标本中,均有基底细胞层液化退变,皮下疱形成,过角化,慢性炎症浸润和胶原退变等改变。在一些病例中由于皮下疱的发展可导致大疱的形成甚至出现溃 The authors studied 25 cases of DLE oral lesion biopsy, HE staining specimens, and proposed the use of only biopsy specimens of oral mucosal lesions to make a diagnosis of DLE. The authors found that in these specimens, there were liquefaction and degeneration of the basal cell layer, subcutaneous hernia formation, hyperkeratosis, chronic inflammatory infiltration and collagen degeneration and other changes. In some cases, the development of subcutaneous fistulas may lead to the formation of bullae or even collapse.