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目的探讨维吾尔族2型糖尿病(T2DM)患者血清空腹C-肽水平与糖尿病(DM)家族史、临床特征的关系,进一步了解DM家族史对T2DM患者残余β细胞功能的影响。方法选取新疆医科大学第一附属医院确诊为T2DM的维吾尔族患者391例,根据有无DM家族史和DM病程进行分组,并比较各组一般资料、血清空腹C-肽水平及血糖、血脂等相关指标。结果 391例患者中有DM家族史123例(31.46%),无DM家族史268例(68.54%);两组在DM病程、体重指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖、血压、血脂及并发症等方面比较,差异无统计学意义(P>0.05),有DM家族史的患者发病年龄较小,收缩压水平低,血清空腹C-肽浓度低;在调整DM病程、BMI、HbA1c、空腹血糖、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白及高密度脂蛋白等指标后,血清空腹C-肽水平与DM家族史呈负相关(P<0.05)。结论在维吾尔族T2DM患者中,DM家族史与血清空腹C-肽水平的逐步下降相关。
Objective To investigate the relationship between fasting C-peptide levels and family history and clinical features of type 2 diabetes mellitus (T2DM) in patients with Uigur type 2 diabetes mellitus (T2DM) and to further understand the influence of DM family history on residual β-cell function in T2DM patients. Methods 391 Uighur patients diagnosed as T2DM in the First Affiliated Hospital of Xinjiang Medical University were selected according to the presence or absence of DM family history and DM course of disease. The levels of fasting C-peptide in serum and blood glucose, index. Results There were 123 cases (31.46%) with DM family history and 268 cases (68.54%) without family history of DM in 391 cases. There was no significant difference in DM course, body mass index (BMI), HbA1c, fasting blood glucose, (P> 0.05). The patients with DM family history had younger age, lower systolic blood pressure, and lower fasting serum C-peptide concentration. In the course of adjusting DM duration, BMI, serum lipids and complications, the difference was not statistically significant HbA1c, fasting blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein, serum fasting C-peptide level was negatively correlated with DM family history (P <0.05). Conclusions In Uighur T2DM patients, the family history of DM is associated with a gradual decline in serum C-peptide levels.