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目的观察雷尼替丁和庆大霉素合剂口服给药后治疗消化性溃疡的疗效。方法62例消化性溃疡患者随机分成两组,对照组雷尼替丁0.15g,bid,饭后服。治疗组服用雷尼替丁同时加服庆大霉素合剂10ml,tid,雷尼替丁用法用量同对照组,6周为一疗程。结果两组近远期疗效显示:6周治疗,两组溃疡愈合率,治疗组为90.3%,对照组为83.9%,近期疗效相同,但幽门螺杆菌清除率治疗组为80.6%,对照组为29.6%,治疗组明显优于对照组(P<0.01)。溃疡复发率6、12个月治疗组明显低于对照组(P<0.01),远期疗效显示治疗组明显优于对照组。结论庆大霉素与雷尼替丁合用可降低溃疡病的复发率。
Objective To observe the curative effect of ranitidine and gentamycin on peptic ulcer after oral administration. Methods 62 cases of peptic ulcer patients were randomly divided into two groups, the control group ranitidine 0.15g, bid, after meals. Treatment group taking ranitidine plus gentamicin mixture 10ml, tid, the amount of ranitidine with the control group, 6 weeks for a course of treatment. Results The short-term and long-term effects of the two groups showed that the curative rate of ulcer in the two groups was 90.3% in the treatment group and 83.9% in the control group in the 6 weeks treatment group, with similar efficacy in the short term, but the rate of Helicobacter pylori eradication group was 80.6% 29.6%, the treatment group was significantly better than the control group (P <0.01). The recurrence rate of ulcer in 6,12 months treatment group was significantly lower than that in control group (P <0.01). The long-term efficacy showed that the treatment group was significantly better than the control group. Conclusions Gentamycin combined with ranitidine can reduce the recurrence rate of ulcer disease.