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目的分析住院甲状腺功能亢进(甲亢)和原发性甲状腺功能减退症患者(甲减)心肌酶谱变化,探讨甲亢、甲减与心肌酶变化的关系。方法随机选取门诊初诊甲亢患者31例、甲减患者27例和健康体检者29例为研究对象,检测晨起空腹静脉血血清天门冬酸氨基转移酶(AST)、肌酸激酶(CK)、CK的同工酶(CK-MB)、乳酸脱氢酶(LDH)、LDH同工酶(HBDH)水平与FT3,FT4,促甲状腺激素(TSH)水平的关系。结果甲减患者血清AST,CK,CK-MB,LDH,HBDH均明显高于对照组(P<0.05);FT3,FT4与AST,CK,CK-MB,LDH,HBDH呈显著负相关,TSH水平与心肌酶谱无相关性。甲亢患者血清AST,CK-MB明显高于对照组(P<0.01),且血清FT3,FT4与AST,CK,CK-MB,LDH,HBDH呈显著正相关,TSH与心肌酶谱各项指标呈显著负相关。结论甲亢和甲减患者常伴心肌酶升高,及时检测心肌酶谱,可辅助评价甲状腺疾病病情以及继发心脏损害的危险性。
Objective To analyze the changes of myocardial enzymes in patients with hyperthyroidism (Hyperthyroidism) and primary hypothyroidism (Hypothyroidism) and to explore the relationship between hyperthyroidism, hypothyroidism and myocardial enzymes. Methods Thirty-one patients with newly diagnosed hyperthyroidism, 27 hypothyroidism patients and 29 healthy subjects were selected randomly from the outpatient clinic. The fasting venous blood serum aspartate aminotransferase (AST), creatine kinase (CK), CK (CK-MB), lactate dehydrogenase (LDH), LDH isoenzyme (HBDH) levels and FT3, FT4, thyroid stimulating hormone (TSH) levels. Results Serum AST, CK, CK-MB, LDH and HBDH in hypothyroidism patients were significantly higher than those in control group (P <0.05). There was a significant negative correlation between FT3 and FT4 and AST, CK, CK- No correlation with myocardial enzymes. The levels of serum AST and CK-MB in patients with hyperthyroidism were significantly higher than those in the control group (P <0.01), and the levels of FT3 and FT4 were positively correlated with AST, CK, CK-MB, LDH and HBDH Significant negative correlation. Conclusion Hyperthyroidism and hypothyroidism patients often accompanied by elevated myocardial enzymes, and timely detection of myocardial enzymes, can help assess the condition of thyroid disease and the risk of secondary heart damage.