氟康唑(Fluconazole)自1988年上市以来,越来越多地被应用于真菌病的治疗。其分子量低、易溶于水、生物利用度高、体内分布广泛、半衰期长的优势在真菌感染的发生方面极具治疗价值。而其较好的耐受性,低而轻微的不良反应较其它吡咯类抗真菌药更有前途。 一、药理 氟康唑特异性地抑制了对真菌 Fluconazole has been increasingly used in the treatment of fungal diseases since it was introduced in 1988. Its low molecular weight, soluble in water, bioavailability, widely distributed in the body, the advantages of long half-life in the occurrence of fungal infection has great therapeutic value. And its better tolerability, low and mild adverse reactions than other azole antifungal drugs more promising. First, pharmacological fluconazole specifically inhibited the fungus